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DeCS
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Descriptor English:
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Tissue Inhibitor of Metalloproteinase-2
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Descriptor Spanish:
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Inhibidor Tisular de Metaloproteinasa-2
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Descriptor Portuguese:
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Inibidor Tecidual de Metaloproteinase-2
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Synonyms English:
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TIMP-2
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Tree Number:
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D12.776.645.875.500
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Definition English:
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A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of TIMP-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo. |
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Pharmacological Action:
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Matrix Metalloproteinase Inhibitors
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History Note English:
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1998; see TISSUE INHIBITOR OF METALLOPROTEINASE-2 (NM) 1989-1997
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Allowable Qualifiers English:
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Record Number:
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33427
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Unique Identifier:
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D019716
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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